Irreplaceable : Alex Voormann, an intense, cerebral thirty-year-old archaeologist, is married to the woman of his dreams - an intelligent, ambitious botanist named Isabel. When Isabel is killed by a reckless driver, Alex reluctantly agrees to donate her heart. Janet Corcoran, a young mother of two and an art teacher at an inner-city school in Chicago, is sick with heart disease. She is on the waiting list for a transplant, but her chances are slim. She watches the Weather Channel, secretly praying for foul weather and car crashes. The day Isabel dies, Janet gets her wish. So begins this extraordinary story about two families whose lives intersect forever in the aftermath of a tragic accident.